Compound ID | 3461

Update compound information

CW-270033

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa; cell wall synthesis inhibitor
Description: Synthetic compound; an injectable thio carbapenem stable to degradation by renal dehydropeptidase I (DHP-I); shows in vivo efficacy in mice infected with Staphylococcus aureus, Pseudomonas aeruginosa, or Escherichia coli
Year first mentioned: 2007
Development status: Experimental
Chemical structure(s):
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Molecular weight: 447.53
Iso. SMILES: C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(=O)O)S[C@@H]1CN[C@H](CC(=N)NS(=O)(=O)N)C1
InChI Key: HHMFMEIZCVVIGF-CEALUIJNSA-N
Can. SMILES: C[C@@H]1[C@@H]2[C@@H]([C@@H](C)O)C(=O)N2C(=C1S[C@H]3C[C@@H](CC(=N)NS(=O)(=O)N)NC3)C(=O)O
InChI: InChI=1S/C16H25N5O6S2/c1-6-12-11(7(2)22)15(23)21(12)13(16(24)25)14(6)28-9-3-8(19-5-9)4-10(17)20-29(18,26)27/h6-9,11-12,19,22H,3-5H2,1-2H3,(H2,17,20)(H,24,25)(H2,18,26,27)/t6-,7-,8+,9+,11-,12-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/275795821
Citation: https://www.jstage.jst.go.jp/article/bpb/30/3/30_3_575/_article/-char/en

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