Compound ID | 3465

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Rhodomyrtone

Class: Natural product antibiotic (acylphloroglucinol)

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus including coagulase-negative strains; membrane-active agent (transiently binds to lipid membrane to form invaginations and lipid vesicles which trap proteins)
Description: Natural product from Rhodomyrtus tomentosa
Year first mentioned: 2008
Development status: Experimental
Chemical structure(s):
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Molecular weight: 442.55
Iso. SMILES: CC(C)C[C@@H]1C2=C(C=C(C(=C2O)C(=O)CC(C)C)O)OC3=C1C(=O)C(C(=O)C3(C)C)(C)C
InChI Key: TYDBFNAOFZIICW-CQSZACIVSA-N
Can. SMILES: CC(C)C[C@@H]1C2=C(C(=C(C=C2OC3=C1C(=O)C(C)(C)C(=O)C3(C)C)O)C(=O)CC(C)C)O
InChI: InChI=1S/C26H34O6/c1-12(2)9-14-18-17(11-16(28)20(21(18)29)15(27)10-13(3)4)32-23-19(14)22(30)25(5,6)24(31)26(23,7)8/h11-14,28-29H,9-10H2,1-8H3/t14-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/12050020
Citations:
  • https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006876#:~:text=Here%2C%20we%20show%20that%20rhodomyrtone,schematically%20depicted%20in%20Fig%2011.
  • https://www.jstage.jst.go.jp/article/jhs/54/5/54_5_589/_article/-char/en

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