Compound ID | 3467
Des-fatty acyl-polymyxin B decapeptide derivative
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Binds to lipopolysaccharide membrane of Gram-negatives |
| Target Pathogen: | Active against Escherichia coli, Salmonella Typhimurium, and Pseudomonas aeruginosa |
| Description: | Semi-synthetic compound; derived from cyclic decapeptide des-fatty acyl-polymyxin B with introduced amino acids; decreased toxicity compared to polymyxin B |
| Year first mentioned: | 2009 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.jstage.jst.go.jp/article/cpb/57/4/57_4_332/_article/-char/en |
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