Compound ID | 3473

Update compound information

E-4501, E4501, E 4501

Synonym(s): E4501  |  E 4501

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, and Clostridium sp.;
Description: Synthetic compound; monofluorinated; superior to ciprofloxacin in protecting mice against systemic infection caused by Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight: 349.33
Iso. SMILES: CNC1CN(C1)c1c(F)cc2c(c1F)n(cc(C(=O)O)c2=O)C1CC1
InChI Key: QSNYNWOQOIJCFV-UHFFFAOYSA-N
Can. SMILES: CNC1CN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)F
InChI: InChI=1S/C17H17F2N3O3/c1-20-8-5-21(6-8)15-12(18)4-10-14(13(15)19)22(9-2-3-9)7-11(16(10)23)17(24)25/h4,7-9,20H,2-3,5-6H2,1H3,(H,24,25)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/274051588
Citation: https://journals.asm.org/doi/10.1128/aac.34.12.2318

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