Compound ID | 3474

Update compound information

E-4500, E4500, E 4500

Synonym(s): E4500  |  E 4500

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, and Clostridium sp.;
Description: Synthetic compound; monofluorinated; superior to ciprofloxacin in protecting mice against systemic infection caused by Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight: 317.32
Iso. SMILES: NC1CN(C1)c1cc2n(cc(C(=O)O)c(=O)c2cc1F)C1CC1
InChI Key: CTJMNBROBOZHAP-UHFFFAOYSA-N
Can. SMILES: C1CC1N2C=C(C(=O)C3=C2C=C(C(=C3)F)N4CC(C4)N)C(=O)O
InChI: InChI=1S/C16H16FN3O3/c17-12-3-10-13(4-14(12)19-5-8(18)6-19)20(9-1-2-9)7-11(15(10)21)16(22)23/h3-4,7-9H,1-2,5-6,18H2,(H,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/274051589
Citation: https://journals.asm.org/doi/10.1128/aac.34.12.2318

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