Compound ID | 3476

Update compound information

E-4474, E4474, E 4474

Synonym(s): E4474  |  E 4474

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, and Clostridium sp.;
Description: Synthetic compound; monofluorinated; superior to ciprofloxacin in protecting mice against systemic infection caused by Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight: 335.31
Iso. SMILES: NC1CN(C1)c1c(F)cc2c(c1F)n(cc(C(=O)O)c2=O)C1CC1
InChI Key: IKZBNCORGKYEDZ-UHFFFAOYSA-N
Can. SMILES: C1CC1N2C=C(C(=O)C3=C2C(=C(C(=C3)F)N4CC(C4)N)F)C(=O)O
InChI: InChI=1S/C16H15F2N3O3/c17-11-3-9-13(12(18)14(11)20-4-7(19)5-20)21(8-1-2-8)6-10(15(9)22)16(23)24/h3,6-8H,1-2,4-5,19H2,(H,23,24)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/274051590
Citation: https://journals.asm.org/doi/10.1128/aac.34.12.2318

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