Compound ID | 3477

Update compound information

E-4441, E4441, E 4441

Synonym(s): E4441  |  E 4441

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, and Clostridium sp.;
Description: Synthetic compound; monofluorinated; superior to ciprofloxacin in protecting mice against systemic infection caused by Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight: 349.33
Iso. SMILES: CC1(CN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)F)N
InChI Key: FEMZVDSBIXDODB-UHFFFAOYSA-N
Can. SMILES: CC1(CN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)F)N
InChI: InChI=1S/C17H17F2N3O3/c1-17(20)6-21(7-17)14-11(18)4-9-13(12(14)19)22(8-2-3-8)5-10(15(9)23)16(24)25/h4-5,8H,2-3,6-7,20H2,1H3,(H,24,25)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/130229
Citation: https://journals.asm.org/doi/10.1128/aac.34.12.2318

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