Compound ID | 3482

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Plantamajoside

Class: Antivirulence agent

Agent Type: Natural product; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Sortase inhibitor
Target Pathogen: Active against Staphylococcus aureus
Description: Natural product from Plantago asiatica L. (Plantaginaceae); efficacious against Staphylococcus aureus infection in Galleria mellonella and mouse pneumonia model; shows synergistic effect with vancomycin
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 640.59
Iso. SMILES: C1=CC(=C(C=C1CCO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OC(=O)/C=C/C3=CC(=C(C=C3)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O)O
InChI Key: KFEFLPDKISUVNR-QJEHNBJNSA-N
Can. SMILES: C1=C(/C=C/C(=O)O[C@@H]2[C@@H](CO)O[C@H]([C@@H]([C@H]2O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)O)OCCC4=CC=C(C(=C4)O)O)C=C(C(=C1)O)O
InChI: InChI=1S/C29H36O16/c30-11-19-22(37)23(38)24(39)29(42-19)45-27-25(40)28(41-8-7-14-2-5-16(33)18(35)10-14)43-20(12-31)26(27)44-21(36)6-3-13-1-4-15(32)17(34)9-13/h1-6,9-10,19-20,22-35,37-40H,7-8,11-12H2/b6-3+/t19-,20-,22-,23+,24-,25-,26-,27-,28-,29+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5281788
Citation: https://journals.asm.org/doi/10.1128/aem.01804-24

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