Compound ID | 3484

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Carbonyl cyanide 3-chlorophenylhydrazone (CCCP)

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Efflux pump inhibitor
Target Pathogen: Active against Mycobacterium abscessus
Description: Synthetic compound; shows synergistic or additive effects with clarithromycin, linezolid, and amikacin
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 204.62
Iso. SMILES: C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N
InChI Key: UGTJLJZQQFGTJD-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N
InChI: InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2603
Citations:
  • https://www.dovepress.com/carbonyl-cyanide-3-chlorophenylhydrazone-cccp-exhibits-direct-antibact-peer-reviewed-fulltext-article-IDR
  • https://journals.asm.org/doi/10.1128/spectrum.01777-24

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