Compound ID | 3485

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MGC-10

Synonym(s): (R,R)-tetrahydrochrysene

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Elongation factor (EF-Tu) inhibitor
Target Pathogen: Active against methicillin and mupirocin-resistant and -susceptible Staphylococcus aureus
Description: Synthetic compound from the LOPAC-1280 (Library of Pharmacologically Active Compounds) chemical library; repurposed estrogen receptor ligand; shows toxicity when administered systemically
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 320.43
Iso. SMILES: OC1=CC=2C[C@@H](CC)C3=C([C@H](CC)CC4=CC(O)=CC=C34)C2C=C1
InChI Key: MASYAWHPJCQLSW-ZIAGYGMSSA-N
Can. SMILES: CC[C@@H]1CC2=CC(=CC=C2C3=C1C4=C(C[C@H]3CC)C=C(C=C4)O)O
InChI: InChI=1S/C22H24O2/c1-3-13-9-15-11-17(23)6-8-20(15)22-14(4-2)10-16-12-18(24)5-7-19(16)21(13)22/h5-8,11-14,23-24H,3-4,9-10H2,1-2H3/t13-,14-/m1/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aem.02046-24

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