Compound ID | 3486
Hs02
Class: Antimicrobial peptide
| Agent Type: | Natural product; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Targets lipopolysaccharides in bacterial outer membrane |
| Target Pathogen: | Active against carbapenem-resistant Escherichia coli and Klebsiella pneumoniae |
| Description: | Natural product from human unconventional myosin protein; an intragenic antimicrobial peptide; prevents biofilm formation and eliminates established biofilms; shows no haemolytic and cytotoxicity at 32 ug/ml vs 2-16 ug/ml MIC; efficacious in Galleria mellonella infection model |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/spectrum.01050-24 |
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