Compound ID | 3489

Update compound information

α-Mangostin derivative 4

Synonym(s): alpha-mangostin derivative 4  |  α-mangostin-4  |  alpha-mangostin-4

Class: Membrane-active agent

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus; membrane-active agent and additionally inhibits MepA and NorA efflux pumps
Description: Semi-synthetic compound; derived from mangostin isolated from Garcinia cambogia with reduced toxicity; shows synergistic effect with penicillin, gentamicin, and enrofloxacin
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 410.46
Iso. SMILES: CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)OC)CC=C(C)C)O)C
InChI Key: GNRIZKKCNOBBMO-UHFFFAOYSA-N
Can. SMILES: CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(CC=C(C)C)C(=C(C=C3O2)O)OC)O)C
InChI: InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5281650
Citation: https://journals.asm.org/doi/10.1128/spectrum.01631-24

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