Compound ID | 3495

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Benzo[c]phenanthridine derivative 6

Synonym(s): BPD-6

Class: Small molecule antibacterial agent

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Efflux pump inhibitor. Likely involves Mmr efflux pump as resistant isolates show upregulation
Target Pathogen: Active against Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium kansasii, and Mycobacterium smegmatis
Propensity to select resistant mutants: Yes
Description: Semi-synthetic compound; derived from the natural product sanguinarine from Sanguinaria canadensis; bacteriostatic
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 352.86
Iso. SMILES: COC1=CC=C(C([N+](C)=CC2=C3C=C(N(C)C)C=C2)=C3C=C4)C4=C1.[Cl-]
InChI Key: FUIUQGBSLLTRMW-UHFFFAOYSA-M
Can. SMILES: CN(C)C1=CC2=C3C=CC4=C(C=CC(=C4)OC)C3=[N+](C)C=C2C=C1.[Cl-]
InChI: InChI=1S/C21H21N2O.ClH/c1-22(2)16-7-5-15-13-23(3)21-18-10-8-17(24-4)11-14(18)6-9-19(21)20(15)12-16;/h5-13H,1-4H3;1H/q+1;/p-1
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.01246-24

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