Compound ID | 3504

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3-de-O-methylsporaricin A sulfate

Synonym(s): K-4619

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, Escherichia coli, Enterobacter spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae; no activity towards strains expressing AAC(3)-I and AAC(3)-III; reduced activity towards strains expressing APH(3')-II; protein synthesis inhibitor
Description: Semi-synthetic compound derived from natural product sporaricin A; effectiveness comparable to sporaricin A in treating mice infection
Institute where first reported: Tokyo Research Laboratories, Kowa Company, Ltd
Year first mentioned: 1982
Development status: Experimental
Chemical structure(s):
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Molecular weight: 571.62
Iso. SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)N(C)C(=O)CN)O)N)N)N.OS(=O)(=O)O.OS(=O)(=O)O
InChI Key: GXEGVOVKMLSAJW-UHFFFAOYSA-N
Can. SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)N(C)C(=O)CN)O)N)N)N.OS(=O)(=O)O.OS(=O)(=O)O
InChI: InChI=1S/C16H33N5O5.2H2O4S/c1-7(18)11-4-3-8(19)16(25-11)26-15-9(20)5-10(22)13(14(15)24)21(2)12(23)6-17;2*1-5(2,3)4/h7-11,13-16,22,24H,3-6,17-20H2,1-2H3;2*(H2,1,2,3,4)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/196235
Citations:
  • https://journals.asm.org/doi/10.1128/aac.26.2.187
  • https://www.sciencedirect.com/science/article/pii/0008621582840305?via%3Dihub

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