Compound ID | 3506

Update compound information

Isorhapontigenin 

Class: Antivirulence agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus; targets the multiple gene regulator A (MgrA) reducing S. aureus adhesion and virulence
Description: Natural product from the herb Gnetum cleistostachyum; has no intrinsic antibacterial effect; shows synergistic effect with vancomycin; protects Galleria mellonella from methicillin-resistant Staphylococcus aureus infection
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 258.27
Iso. SMILES: COC1=C(C=CC(=C1)/C=C/C2=CC(=CC(=C2)O)O)O
InChI Key: ANNNBEZJTNCXHY-NSCUHMNNSA-N
Can. SMILES: COC1=CC(=CC=C1O)/C=C/C2=CC(=CC(=C2)O)O
InChI: InChI=1S/C15H14O4/c1-19-15-8-10(4-5-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5318650
Citations:
  • https://journals.asm.org/doi/10.1128/msphere.00317-24
  • https://journals.asm.org/doi/10.1128/aac.00611-24

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.