Compound ID | 3508

Update compound information

Serrawettin W2-FL10

Synonym(s): W2-FL10

Class: Lipopeptide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis; membrane-active agent
Description: Semi-synthetic compound derived from natural product serrawettin W2 from Serratia marcescens NP2; shows low selectivity index (5.1 to 9.1);
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 731.92
Iso. SMILES: CCCCCCCC1CC(=O)N[C@@H](C(=O)N[C@H](C(=O)NC(C(=O)N[C@@H](C(=O)N[C@H](C(=O)O1)[C@@H](C)CC)CC2=CC=CC=C2)[C@@H](C)O)CO)CC(C)C
InChI Key: JJJUZZODDZXKCZ-XVPNFOEFSA-N
Can. SMILES: CCCCCCCC1CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NC([C@@H](C)O)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O1
InChI: InChI=1S/C38H61N5O9/c1-7-9-10-11-15-18-27-21-31(46)39-28(19-23(3)4)34(47)41-30(22-44)36(49)43-33(25(6)45)37(50)40-29(20-26-16-13-12-14-17-26)35(48)42-32(24(5)8-2)38(51)52-27/h12-14,16-17,23-25,27-30,32-33,44-45H,7-11,15,18-22H2,1-6H3,(H,39,46)(H,40,50)(H,41,47)(H,42,48)(H,43,49)/t24-,25+,27?,28+,29+,30-,32-,33?/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/164436
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.jnatprod.1c01186
  • https://journals.asm.org/doi/10.1128/spectrum.02952-23

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