Compound ID | 3511
EC1
Synonym(s): Endolytix Cocktail 1
Class: Bacteriophage and/or bacteriophage-derived product
| Agent Type: | Direct acting; Bacteriophage or bacteriphage-derived product; |
| Spectrum of activity: | Antimycobacterial |
| Mechanism of action: | Mycolic acid synthesis inhibitor. Hydrolyzes linkage of arabinogalactan and mycolic acid (degrades mycobacterial cell envelope; cell wall synthesis inhibitor) |
| Target Pathogen: | Active against nontuberculous mycobacteria and Mycobacterium tuberculosis |
| Description: | Mycobacteriophage lysin enzyme cocktail; contains LysA , LysB, α-amylase, and isoamylase enzymes; shows synergistic effect with standard-of-care antimycobacterials |
| Institute where first reported: | Endolytix Technology Inc. |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/spectrum.03534-23 |
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