Compound ID | 3513

Update compound information

Thiazolidinone derivative

Synonym(s): TD-H2-A

Class: Small molecule antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecalis, and Listeria monocytogenes; likely targets Walk-HK
Description: Synthetic compound; {2-{4-{3-(2-ethylphenyl)−2-[(2-ethylphenyl)imino]−4-oxothiazolidin-5-ylidene}methyl}−2-methoxyphenoxy}acetic acid; shows no cytotoxicity towards Vero cells at 4-31x MIC and low minimal haemolytic activity towards human red blood cells; shows antibacterial activity on established Staphylococcus aureus biofilms
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 500.95
Iso. SMILES: C1C=CC(N2/C(=N\C3C=CC(Cl)=CC=3)/S/C(=C\C3OC(C4C=CC(C(O)=O)=CC=4)=CC=3)/C2=O)=CC=1
InChI Key: JIMSGNRWXRFDRD-OLCXPRTASA-N
Can. SMILES: C1=CC=C(C=C1)N/2C(=O)/C(=C/C3=CC=C(C4=CC=C(C=C4)C(=O)O)O3)/S\C2=N\C5=CC=C(C=C5)Cl
InChI: InChI=1S/C27H17ClN2O4S/c28-19-10-12-20(13-11-19)29-27-30(21-4-2-1-3-5-21)25(31)24(35-27)16-22-14-15-23(34-22)17-6-8-18(9-7-17)26(32)33/h1-16H,(H,32,33)/b24-16-,29-27+
External links:
Citation: https://journals.asm.org/doi/10.1128/spectrum.02327-23

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