Compound ID | 352

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M14659 (GR 63116)

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Pseudomonas sp. and Staphylococcus aureus
Description: Injectable cephalosporin
Institute where first reported: Mochida Pharmaceutical; Ajinomoto; GSK, USA
Year first mentioned: 1986
Highest development stage: Phase 1
Development status: Inactive
Chemical structure(s):
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Molecular weight: 757.74
Iso. SMILES: CC1=NC2=NC(=NN2C(=C1)SCC3=C(N4[C@@H]([C@@H](C4=O)NC(=O)/C(=N\O[C@@H](C5=CC(=C(C=C5)O)O)C(=O)O)/C6=CN=C(S6)N)SC3)C(=O)O)C(=O)O
InChI Key: PBJHSJKHPMHQSC-HTAGMMKPSA-N
Can. SMILES: CC1=NC2=NC(=NN2C(=C1)SCC3=C(C(=O)O)N4C(=O)[C@H]([C@H]4SC3)NC(=O)/C(=N\O[C@@H](C5=CC=C(C(=C5)O)O)C(=O)O)/C6=CN=C(N)S6)C(=O)O
InChI: InChI=1S/C28H23N9O11S3/c1-9-4-15(37-28(31-9)33-20(34-37)26(46)47)49-7-11-8-50-23-17(22(41)36(23)18(11)24(42)43)32-21(40)16(14-6-30-27(29)51-14)35-48-19(25(44)45)10-2-3-12(38)13(39)5-10/h2-6,17,19,23,38-39H,7-8H2,1H3,(H2,29,30)(H,32,40)(H,42,43)(H,44,45)(H,46,47)/b35-16-/t17-,19+,23-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6540697
Guide to Pharmacology: M14659
Citations:
  • https://books.google.co.uk/books?id=GgPoCAAAQBAJ&pg=PA308&lpg=PA308&dq=LY173013&source=bl&ots=spuNwNoFKJ&sig=jTjiVJirHIj6GLgqaVt76y91ThA&hl=en&sa=X&ei=4ct2Vc6bLMOBU_e3gHA&ved=0CDcQ6AEwBg#v=onepage&q=LY173013&f=false [Accessed 9 Jun. 2015].
  • https://www.ncbi.nlm.nih.gov/pubmed/3130365

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