Compound ID | 3520

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Bilothiazole E

Class: Natural product antibiotic (thiazole)

Spectrum of activity: Gram-positive
Details of activity: Studies on mode of action suggest this compound is a DNA synthesis inhibitor
Description: Natural product from an identified biosynthetic gene cluster belonging to the human microbiome isolate Bilophila strain; induced DNA-repair repression whole-cell biosensor
Year first mentioned: 2025
Development status: Experimental
Chemical structure(s):
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Molecular weight: 320.39
Iso. SMILES: OC1=C(C2=NC(C3=N[C@@](C(O)=O)([H])CS3)=CS2)C=CC(C)=C1[H]
InChI Key: RTOHVELJNDOFGJ-JTQLQIEISA-N
Can. SMILES: CC1=C([H])C(=C(C=C1)C2=NC(=CS2)C3=N[C@@]([H])(CS3)C(=O)O)O
InChI: InChI=1S/C14H12N2O3S2/c1-7-2-3-8(11(17)4-7)12-15-9(5-20-12)13-16-10(6-21-13)14(18)19/h2-5,10,17H,6H2,1H3,(H,18,19)/t10-/m0/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acssynbio.5c00042

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