Compound ID | 3524

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CVH-88

Synonym(s): CVH88  |  CVH 88

Class: Pleuromutilin 

Spectrum of activity: Gram-positive
Details of activity: Only active against Staphylococcus aureus including methicillin-resistant strain; protein synthesis inhibitor (binds to A- and P-site of the peptidyl transferase center in the 50S ribosomal subunit)
Description: Semi-synthetic compound; a triaromatic C22-conjugated pleuromutilin scaffold; shows no cytotoxicity towards Caco-2 cells
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 652.79
Iso. SMILES: NC1=NC=NC2=C1N=CN2CC3=CC=C(C4=CN(CC(O[C@H]5C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@]6(CCC7=O)[C@]7([H])[C@]5([C@H](C)CC6)C)=O)N=N4)C=C3
InChI Key: HQIWDRDUCRRUSF-DRZNMQGPSA-N
Can. SMILES: C=C[C@]1(C)C[C@@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@]23[H])[C@@H](C)[C@@H]1O)OC(=O)CN4C=C(C5=CC=C(C=C5)CN6C=NC7=C6N=CN=C7N)N=N4
InChI: InChI=1S/C36H44N8O4/c1-6-34(4)15-27(35(5)21(2)11-13-36(22(3)31(34)47)14-12-26(45)30(35)36)48-28(46)18-44-17-25(41-42-44)24-9-7-23(8-10-24)16-43-20-40-29-32(37)38-19-39-33(29)43/h6-10,17,19-22,27,30-31,47H,1,11-16,18H2,2-5H3,(H2,37,38,39)/t21-,22+,27+,30+,31+,34-,35+,36+/m1/s1
External links:
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01328
  • https://amr-conference.com/wp-content/uploads/2025/01/Heidtmann.pdf

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