Compound ID | 3530

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BT-33

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus including strains expressing ermB, cfr, ermA, vgaA, and lnuA, vancomycin-resistant Enterococcus faecium, vancomycin-resistant Enterococcus faecalis expressing lsaAEscherichia coli, and fluoroquinolone-resistant Klebsiella pneumoniae
Description: Synthetic compound; contains oxepanoprolinamid/ cresomycin scaffold with improved spectrum of activity and stability in murine microsomal metabolism
Year first mentioned: 2024
Development status: Experimental
Chemical structure(s):
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Molecular weight: 546.74
Iso. SMILES: CC[C@H](F)C/C=C\[C@@H](C)[C@@H](NC([C@]1([H])[C@@](OCC[C@@H](CC(C)C)C2)([H])[C@]2([H])CN1)=O)[C@@H](O3)[C@H](O)[C@H](O)[C@@H](O)[C@H]3S
InChI Key: VKMZUYFDSYDYMZ-MHEVOAQRSA-N
Can. SMILES: CC[C@@H](C/C=C\[C@@H](C)[C@H]([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)S)O)O)O)NC(=O)[C@]2([H])[C@@]3([H])[C@@]([H])(C[C@@H](CCO3)CC(C)C)CN2)F
InChI: InChI=1S/C27H47FN2O6S/c1-5-18(28)8-6-7-15(4)19(25-22(32)21(31)23(33)27(37)36-25)30-26(34)20-24-17(13-29-20)12-16(9-10-35-24)11-14(2)3/h6-7,14-25,27,29,31-33,37H,5,8-13H2,1-4H3,(H,30,34)/b7-6-/t15-,16+,17+,18+,19-,20+,21+,22-,23-,24-,25-,27-/m1/s1
External links:
Guide to Pharmacology: BT-33
Citations:
  • https://amr-conference.com/wp-content/uploads/2025/01/Payne.pdf
  • https://chemrxiv.org/engage/chemrxiv/article-details/66f5783acec5d6c1424b65a5

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