Compound ID | 3534

Update compound information

5-Nitrofuran-2-carbohydrazide 21f

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhimurium, Klebsiella pneumoniae, Escherichia coli, and Mycobacterium tuberculosis; folate synthesis inhibitor (DHPS inhibitor)
Description: Synthetic compound; sulfonamide derivative; also shows activity against fungi (but not yeast); selectivity index against breast MDA-MB-231 cells is >12.8
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 428.81
Iso. SMILES: O=[N+]([O-])C1=CC=C(C(N/N=C(/C(Cl)=N/NC2=CC=C(S(=O)(N)=O)C=C2)C)=O)O1
InChI Key: LOVBGONXBDHBDR-RXLGVSELSA-N
Can. SMILES: C/C(=N\NC(=O)C1=CC=C([N+](=O)[O-])O1)/C(=N/NC2=CC=C(C=C2)S(=O)(=O)N)/Cl
InChI: InChI=1S/C14H13ClN6O6S/c1-8(17-20-14(22)11-6-7-12(27-11)21(23)24)13(15)19-18-9-2-4-10(5-3-9)28(16,25)26/h2-7,18H,1H3,(H,20,22)(H2,16,25,26)/b17-8+,19-13-
External links:
Citation: https://www.jstage.jst.go.jp/article/bpb/38/10/38_b15-00439/_html/-char/en

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