Compound ID | 3537

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6-Phenylnicotinohydrazide derivative 8b

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Mycobacterium tuberculosis, Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Escherichia coli
Description: Synthetic compound; 6-phenyl-nicotinohydrazide derivative; also shows antifungal activity (fungi and yeast); shows cytotoxicity towards normal breast cells at IC50 127.7 uM (vs MIC ~8.5 uM)
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 463.15
Iso. SMILES: BrC1=CC=C(C2=CC=C(C(N/N=C/C3=C(Cl)C=CC=C3Cl)=O)C(C)=N2)C=C1
InChI Key: WCIJWPRFVZSITE-BHGWPJFGSA-N
Can. SMILES: CC1=C(C=CC(=N1)C2=CC=C(C=C2)Br)C(=O)N/N=C/C3=C(C=CC=C3Cl)Cl
InChI: InChI=1S/C20H14BrCl2N3O/c1-12-15(9-10-19(25-12)13-5-7-14(21)8-6-13)20(27)26-24-11-16-17(22)3-2-4-18(16)23/h2-11H,1H3,(H,26,27)/b24-11+
External links:
Citation: https://www.jstage.jst.go.jp/article/bpb/40/11/40_b17-00361/_article/-char/en

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