Compound ID | 3543

Update compound information

Benzofuroxan derivative 8

Synonym(s): Compound 8  |  (E)-6-((2-Isonicotinoylhydrazono)methyl)benzo[c][1,2,5]- oxadiazole 1-oxide

Class: Protein synthesis inhibitor

Details of activity: Active against Mycobacterium tuberculosis; protein synthesis inhibitor (suspected as translation initiation inhibitor)
Description: Synthetic compound; shows IC50 cytotoxicity towards MRC-5 cell lines at 147.10 mg/L vs MIC at 0.31 mg/L (selectivity index at >400); shows efficacy in mouse model and in macrophage model of infection
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 283.24
Iso. SMILES: C1=CC2=NO[N+](=C2C=C1/C=N\NC(=O)C3=CC=NC=C3)[O-]
InChI Key: VJMQKZDATXNVBK-NVNXTCNLSA-N
Can. SMILES: C1=CC2=NO[N+](=C2C=C1/C=N\NC(=O)C3=CC=NC=C3)[O-]
InChI: InChI=1S/C13H9N5O3/c19-13(10-3-5-14-6-4-10)16-15-8-9-1-2-11-12(7-9)18(20)21-17-11/h1-8H,(H,16,19)/b15-8-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/172021195
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01332

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