Compound ID | 3544

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Bortezomib derivative 58

Synonym(s): Velcade

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Mycobacterium tuberculosis
Description: Synthetic compound; derived from the human proteosome anticancer drug bortezomib; designed to reduce cytotoxicity
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 447.3
Iso. SMILES: OB(O)[C@H](CCC1=CC=CC=C1)NC([C@H](CCC2=NC=CC=C2)NC(C3=NC=CN=C3)=O)=O
InChI Key: IDYQNRQZLZCLIX-FPOVZHCZSA-N
Can. SMILES: C1=CC=C(C=C1)CC[C@@H](B(O)O)NC(=O)[C@H](CCC2=NC=CC=C2)NC(=O)C3=CN=CC=N3
InChI: InChI=1S/C23H26BN5O4/c30-22(29-21(24(32)33)12-9-17-6-2-1-3-7-17)19(11-10-18-8-4-5-13-26-18)28-23(31)20-16-25-14-15-27-20/h1-8,13-16,19,21,32-33H,9-12H2,(H,28,31)(H,29,30)/t19-,21-/m0/s1
External links:
Citation: https://journals.asm.org/doi/full/10.1128/aac.02307-16?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

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