Compound ID | 3545
SATB-082
Synonym(s): cyclohexylgriselimycin | CGM
Class: DNA synthesis inhibitor (DnaN inhibitor)
| Details of activity: | Active against Mycobacterium tuberculosis (including nonreplicating cells in vivo); DNA replication inhibitor (DNA polymerase sliding clamp inhibitor [DnaN inhibitor]) |
| Description: | Semi-synthetic compound; derived from natural product griselimycin; shows activity including in macrophage-like model; ADMET properties superior to griselimycin |
| Institute where first reported: | Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology, Saarland University, 66123 Saarbrücken, Germany; Sanofi-Aventis R&D |
| Year first mentioned: | 2015 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubmed.ncbi.nlm.nih.gov/26045430/ |
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