Compound ID | 3545
SATB-082
Synonym(s): cyclohexylgriselimycin | CGM
Class: Small molecule antibacterial agent
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Antimycobacterial |
| Mechanism of action: | DNA synthesis inhibitor. DNA replication inhibitor; DNA polymerase sliding clamp inhibitor (DnaN inhibitor) |
| Target Pathogen: | Active against Mycobacterium tuberculosis (including nonreplicating cells in vivo) |
| Description: | Semi-synthetic compound; derived from natural product griselimycin; shows activity including in macrophage-like model; ADMET properties superior to griselimycin |
| Institute where first reported: | Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology, Saarland University, 66123 Saarbrücken, Germany; Sanofi-Aventis R&D |
| Year first mentioned: | 2015 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubmed.ncbi.nlm.nih.gov/26045430/ |
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