Compound ID | 3546

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GSK 724A

Synonym(s): DG167  |  GSK3011724A

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Mycolic acid synthesis inhibitor. KasA inhibitor
Target Pathogen: Active against Mycobacterium tuberculosis
Propensity to select resistant mutants: Yes, 10^-7 mutation frequency at 10x MIC
Description: Synthetic compound; shows no cytotoxicity towards HepG2 at >100 uM (highest tested vs MIC at 0.8 uM)
Institute where first reported: GlaxoSmithKline
Year first mentioned: 2016
Development status: Experimental
Chemical structure(s):
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Molecular weight: 267.35
Iso. SMILES: CCCCS(=O)(=O)NC1=CC2=C(C=C1)C=NN2C
InChI Key: DDWBORAVXJGWPK-UHFFFAOYSA-N
Can. SMILES: CCCCS(=O)(=O)NC1=CC2=C(C=C1)C=NN2C
InChI: InChI=1S/C12H17N3O2S/c1-3-4-7-18(16,17)14-11-6-5-10-9-13-15(2)12(10)8-11/h5-6,8-9,14H,3-4,7H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/70689295
Citations:
  • https://journals.asm.org/doi/10.1128/mbio.02101-17?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
  • https://www.nature.com/articles/ncomms12581
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00493

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