Compound ID | 3551

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NITD-349

Synonym(s): Indolcarboxamide analogue

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Mycolic acid synthesis inhibitor. Mycolic acid transporter inhibitor; MmpL3 inhibitor
Target Pathogen: Active against Mycobacterium tuberculosis including multidrug-resistant strains
Description: Synthetic compound; indolcarboxamide analogue; shows efficacy in treating chronic and acute Mycobacterium tuberculosis infection in mouse models; shows synergistic effect with antituberculosis drugs
Institute where first reported: Novartis Institute for Tropical Diseases, Singapore
Year first mentioned: 2013
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 306.35
Iso. SMILES: CC1(CCC(CC1)NC(=O)C2=CC3=C(N2)C=C(C=C3F)F)C
InChI Key: UATYSFRIVIHVKL-UHFFFAOYSA-N
Can. SMILES: CC1(C)CCC(CC1)NC(=O)C2=CC3=C(C=C(C=C3F)F)N2
InChI: InChI=1S/C17H20F2N2O/c1-17(2)5-3-11(4-6-17)20-16(22)15-9-12-13(19)7-10(18)8-14(12)21-15/h7-9,11,21H,3-6H2,1-2H3,(H,20,22)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/72711190
Guide to Pharmacology: NITD-349
Citation: https://journals.asm.org/doi/full/10.1128/aac.02399-16?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

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