NITD-349

Synonym(s): Indolcarboxamide analogue

Class: Mycobacterial cell wall synthesis inhibitor

Details of activity:	Active against Mycobacterium tuberculosis including multidrug-resistant strains; mycobacterial cell wall synthesis inhibitor (mycolic acid transporter inhibitor [MmpL3 inhibitor])
Description:	Synthetic compound; indolcarboxamide analogue; shows efficacy in treating chronic and acute Mycobacterium tuberculosis infection in mouse models; shows synergistic effect with antituberculosis drugs
Institute where first reported:	Novartis Institute for Tropical Diseases, Singapore
Year first mentioned:	2013
Highest developmental phase:	Preclinical
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC1(C)CCC(CC1)NC(=O)C2=CC3=C(C=C(C=C3F)F)N2
Isomeric SMILES:	CC1(CCC(CC1)NC(=O)C2=CC3=C(N2)C=C(C=C3F)F)C
InChI:	InChI=1S/C17H20F2N2O/c1-17(2)5-3-11(4-6-17)20-16(22)15-9-12-13(19)7-10(18)8-14(12)21-15/h7-9,11,21H,3-6H2,1-2H3,(H,20,22)
InChI Key:	UATYSFRIVIHVKL-UHFFFAOYSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/72711190
Main Source:	https://journals.asm.org/doi/full/10.1128/aac.02399-16?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org