Compound ID | 3552

Update compound information

JSF-3285

Class: Mycolic acid synthesis inhibitor

Details of activity: Active against Mycobacterium tuberculosis; mycolic acid synthesis inhibitor (KasA inhibitor)
Description: Synthetic compound; derivative of DG167 (GSK724A) with improved metabolic stability, mouse plasma pharmacokinetics , potency, and in vivo efficacy
Institute where first reported: Rutgers University – New Jersey Medical School, Newark, NJ, USA
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 285.34
Iso. SMILES: CC1=C2C=C(C=CC2=NN1)NS(=O)(=O)CCCCF
InChI Key: AHVAAGWAEHSRBU-UHFFFAOYSA-N
Can. SMILES: CC1=C2C=C(C=CC2=NN1)NS(=O)(=O)CCCCF
InChI: InChI=1S/C12H16FN3O2S/c1-9-11-8-10(4-5-12(11)15-14-9)16-19(17,18)7-3-2-6-13/h4-5,8,16H,2-3,6-7H2,1H3,(H,14,15)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/137523337
Citation: https://www.sciencedirect.com/science/article/pii/S2451945620300714?via%3Dihub

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