JSF-3285

Class: Mycolic acid synthesis inhibitor

Details of activity:	Active against Mycobacterium tuberculosis; mycolic acid synthesis inhibitor (KasA inhibitor)
Description:	Synthetic compound; derivative of DG167 (GSK724A) with improved metabolic stability, mouse plasma pharmacokinetics , potency, and in vivo efficacy
Institute where first reported:	Rutgers University – New Jersey Medical School, Newark, NJ, USA
Year first mentioned:	2020
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC1=C2C=C(C=CC2=NN1)NS(=O)(=O)CCCCF
Isomeric SMILES:	CC1=C2C=C(C=CC2=NN1)NS(=O)(=O)CCCCF
InChI:	InChI=1S/C12H16FN3O2S/c1-9-11-8-10(4-5-12(11)15-14-9)16-19(17,18)7-3-2-6-13/h4-5,8,16H,2-3,6-7H2,1H3,(H,14,15)
InChI Key:	AHVAAGWAEHSRBU-UHFFFAOYSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/137523337
Main Source:	https://www.sciencedirect.com/science/article/pii/S2451945620300714?via%3Dihub