Compound ID | 3559

Update compound information

11726172

Class: Membrane-active agent

Details of activity: Active against Mycobacterium tuberculosis including latent form; membrane-active agent (perturbs cell membrane) and disrupts metal homeostasis
Description: Synthetic compound; 4-nitro-2,1,3-benzothiadiazol-5-yl-1,3-thiazolidine-3-carbodithioate; improved activity in the presence of copper including at subinhibitory copper concentrations; shows efficacy in murine tuberculosis infection model
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 344.46
Iso. SMILES: S=C(SC1=C([N+]([O-])=O)C2=NSN=C2C=C1)N3CSCC3
InChI Key: SXZXLMSTCPLRLO-UHFFFAOYSA-N
Can. SMILES: C1=CC(=C(C2=NSN=C12)[N+](=O)[O-])SC(=S)N3CCSC3
InChI: InChI=1S/C10H8N4O2S4/c15-14(16)9-7(2-1-6-8(9)12-20-11-6)19-10(17)13-3-4-18-5-13/h1-2H,3-5H2
External links:
Citation: https://journals.asm.org/doi/10.1128/msphere.00369-22

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