ME1228 (sulphur analogue of OCP9176)

Class: Beta-lactam (cephalosporin)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Against Klebsiella pneumoniae, Proteus mirabalis and Pseudomonas aeruginosa, ME1228 is more potent than cefpirome, ceftazidime and flomoxef.
Institute where first reported:	Meiji Seika Kaisha (Meiji Seika Pharma., Japan)
Year first mentioned:	1987
Highest developmental phase:	Phase 2
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CC[N+]1=CC=C(C=C1)SCC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N/O[C@@H](C)C(=O)O)/C4=CSC(=N4)N
Isomeric SMILES:	CC[N+]1=CC=C(C=C1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N/O[C@@H](C)C(=O)O)/C4=CSC(=N4)N)SC2)C(=O)[O-]
InChI:	InChI=1S/C23H24N6O7S3/c1-3-28-6-4-13(5-7-28)37-8-12-9-38-20-16(19(31)29(20)17(12)22(34)35)26-18(30)15(14-10-39-23(24)25-14)27-36-11(2)21(32)33/h4-7,10-11,16,20H,3,8-9H2,1-2H3,(H4-,24,25,26,30,32,33,34,35)/b27-15+/t11-,16+,20+/m0/s1
InChI Key:	HJXPKHCLLLRQDL-HFCXZPKYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9577434

External links:
Guide to Pharmacology:	ME-1228 acid
Main Source:	https://journals.asm.org/doi/epdf/10.1128/aac.33.8.1260
Citation:	https://journals.asm.org/doi/epdf/10.1128/aac.33.8.1260