Compound ID | 3564

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XT17 

Class: Membrane-active agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa; membrane-active agent (targets the lipoteichoic acid or lipopolysaccharide) and additionally binds to DNA gyrase (DNA gyrase inhibitor)
Description: Semi-synthetic compound; xanthone derivative; shows low haemolytic activity (>200 mg/ml vs MIC at 0.39~3.125 mg/L) and cytotoxicity (>50 mg/L vs MIC 0.39~3.125 mg/L) towards mammalian cells
Year first mentioned: 2025
Development status: Experimental
Chemical structure(s):
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Molecular weight: 510.59
Iso. SMILES: O=C1C2=C(C=C(OCCCNC(N)=N)C=C2OC/C=C(C)/C)OC3=CC(OCCCNC(N)=N)=CC=C31
InChI Key: GXIVKACJAKFICO-UHFFFAOYSA-N
Can. SMILES: C/C(=C\COC1=CC(=CC2=C1C(=O)C3=CC=C(C=C3O2)OCCCNC(=N)N)OCCCNC(=N)N)/C
InChI: InChI=1S/C26H34N6O5/c1-16(2)7-12-36-21-14-18(35-11-4-9-32-26(29)30)15-22-23(21)24(33)19-6-5-17(13-20(19)37-22)34-10-3-8-31-25(27)28/h5-7,13-15H,3-4,8-12H2,1-2H3,(H4,27,28,31)(H4,29,30,32)
External links:
Citation: https://www.science.org/doi/10.1126/sciadv.adt4723

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