Compound ID | 3569
ZnBq/Ce6@ZIF-8@OMV
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Acinetobacter baumannii |
| Description: | Synthetic compound; contains a small molecule antibacterial metal complex [Zn(Bq)2], drug carrier platform [zeolitic imidazolate framework-8 (ZIF-8)], chlorin e6 [Ce6] to visualise bacterial uptake then coated with outer membrane vesicle [OMV] as drug delivery system; biomimetic nanoparticles |
| Year first mentioned: | 2024 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.science.org/doi/10.1126/sciadv.adk6331 |
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