Cefluprenam

Synonym(s): E1077

Class: Beta-lactam (cephalosporin)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Broad spectrum antibiotic, active against aerobes, anaerobes, Gram positives and negatives. It was in pre-register phase in Japan but was discontinued.
Institute where first reported:	Eisai Co Ltd, Japan
Year first mentioned:	1991
Highest developmental phase:	Phase 3
Development status:	Inactive
Reason Dropped:	Cephalosporins with a quaternary nitrogen such as E-1077 interfere with carnitine metabolism (1).

Chemical structure(s):
Canonical SMILES:	CC[N+](C)(C/C=C/C1=C(C(=O)[O-])N2C(=O)[C@H]([C@H]2SC1)NC(=O)/C(=N\OCF)/C3=NSC(=N3)N)CC(=O)N
Isomeric SMILES:	CC[N+](C)(C/C=C/C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OCF)/C3=NSC(=N3)N)SC1)C(=O)[O-])CC(=O)N
InChI:	InChI=1S/C20H25FN8O6S2/c1-3-29(2,7-11(22)30)6-4-5-10-8-36-18-13(17(32)28(18)14(10)19(33)34)24-16(31)12(26-35-9-21)15-25-20(23)37-27-15/h4-5,13,18H,3,6-9H2,1-2H3,(H5-,22,23,24,25,27,30,31,33,34)/b5-4+,26-12-/t13-,18-,29?/m1/s1
InChI Key:	XAKKNLNAJBNLPC-MAYKBZFQSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6536774

External links:
Guide to Pharmacology:	cefluprenam
Citation:	https://journals.asm.org/doi/10.1128/aac.36.9.1894