Compound ID | 3571

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Sviceucin

Class: Antimicrobial peptide

Agent Type: Natural product;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus and Enterococcus faecalis
Description: Natural product from Streptomyces sviceus; restores susceptibility to vancomycin in VanB-expressing strains; shows weak intrinsic activity; shows antivirulence propertiesl; a lasso peptide
Year first mentioned: 2025
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight:
Iso. SMILES: CC[C@H](C)[C@H]1C(=O)N[C@@H](CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@H]3CC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC4=CNC5=CC=CC=C54)C)[C@@H](C)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CC6=CC=CC=C6)CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N2)CC(=O)O)CC7=CNC8=CC=CC=C87)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)O
InChI Key: SLPRSALLYDJDLY-CJSAPLTJSA-N
Can. SMILES: CC[C@H](C)[C@H]1C(=O)N[C@@H](CSSC[C@H]2C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=CNC5=C4C=CC=C5)C(=O)N1)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC6=CC=CC=C6)NC3=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC7=CNC8=C7C=CC=C8)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)O
InChI: InChI=1S/C92H126N22O26S4/c1-12-45(8)74-89(136)109-65(86(133)112-73(44(6)7)92(139)140)41-144-143-40-64-87(134)114-76(48(11)116)91(138)107-60-30-66(117)101-63(85(132)111-72(43(4)5)88(135)106-58(28-50-32-93-54-24-18-16-22-52(50)54)79(126)96-34-67(118)95-35-68(119)100-61(31-71(122)123)83(130)108-64)39-142-141-38-62(102-69(120)36-97-78(125)56(26-42(2)3)104-81(128)57(105-82(60)129)27-49-20-14-13-15-21-49)80(127)98-37-70(121)110-75(47(10)115)90(137)99-46(9)77(124)103-59(84(131)113-74)29-51-33-94-55-25-19-17-23-53(51)55/h13-25,32-33,42-48,56-65,72-76,93-94,115-116H,12,26-31,34-41H2,1-11H3,(H,95,118)(H,96,126)(H,97,125)(H,98,127)(H,99,137)(H,100,119)(H,101,117)(H,102,120)(H,103,124)(H,104,128)(H,105,129)(H,106,135)(H,107,138)(H,108,130)(H,109,136)(H,110,121)(H,111,132)(H,112,133)(H,113,131)(H,114,134)(H,122,123)(H,139,140)/t45-,46-,47+,48+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,72-,73-,74-,75-,76-/m0/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/177746928
Guide to Pharmacology: sviceucin
Citations:
  • https://pubs.acs.org/doi/10.1021/acschembio.5b00584
  • https://www.cell.com/iscience/fulltext/S2589-0042(25)00182-8

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