Compound ID | 3573

Update compound information

NSC 18725

Synonym(s): NSC18725  |  NSC-18725  |  3,5-Dimethyl-4-nitroso-1-phenlpyrazole

Class: Small molecule antibacterial agent

Details of activity: Active against Mycobacteria sp. including Mycobacterium bovis, Mycobacterium smegmatis, and Mycobacterium tuberculosis; induces autophagy leading to growth inhibition of Mycobacterium tuberculosis in human macrophages
Propensity to select resistant mutants: No
Description: Synthetic compound identified from the National Institutes of Health Open Set II or Oncology Set V small molecule library; potentiates anti-mycobacterial drugs in clinical use and those under clinical trials
Institute where first reported: Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, Faridabad, India
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 201.22
Iso. SMILES: CC1=C(C(=NN1C2=CC=CC=C2)C)N=O
InChI Key: SCHFUNOUOHIHSX-UHFFFAOYSA-N
Can. SMILES: CC1=NN(C(=C1N=O)C)C2=CC=CC=C2
InChI: InChI=1S/C11H11N3O/c1-8-11(13-15)9(2)14(12-8)10-6-4-3-5-7-10/h3-7H,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/12853
Citation: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.03051/full

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