Compound ID | 3579
Lariocidin B
Class: Antimicrobial peptide (lasso peptide)
| Spectrum of activity: | Gram-negative |
| Details of activity: | Active against Acinetobacter baumannii and Mycobacterium smegmatis; protein synthesis inhibitor (binds to the16S ribosomal RNA and aminoacyl-tRNA to inhibit translocation and cause misreading) |
| Description: | Natural product from Paenibacillus sp. M2; shows efficacy in treating Acinetobacter baumannii in mouse neutropenic thigh infection model |
| Institute where first reported: | David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada |
| Year first mentioned: | 2025 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.nature.com/articles/s41586-025-08723-7 |
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