Compound ID | 3588

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O-Demethylfortimicin A

Synonym(s): A49759  |  ODMF

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterobacter sp., Serratia marcescens, Shigella sp., and Salmonella sp.; protein synthesis inhibitor
Description: Semisynthetic compound derived from the natural product fortimicin A; shows synergistic effect with carbenicillin; shows efficacy in mice infected with Klebsiella pneumoniae. Staphylococcus aureus, Escherichia coli, or Pseudomonas aeruginosa
Institute where first reported: Abbott Laboratories
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 391.46
Iso. SMILES: C[C@@H]([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@@H]([C@H]([C@H]2O)N(C)C(=O)CN)O)O)N)N)N
InChI Key: OWTJVZIKRRJXGS-MAEXYVIMSA-N
Can. SMILES: C[C@@H]([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@@H]([C@H]([C@H]2O)N(C)C(=O)CN)O)O)N)N)N
InChI: InChI=1S/C16H33N5O6/c1-6(18)8-4-3-7(19)16(26-8)27-15-10(20)12(23)13(24)11(14(15)25)21(2)9(22)5-17/h6-8,10-16,23-25H,3-5,17-20H2,1-2H3/t6-,7+,8-,10-,11+,12-,13+,14+,15+,16+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/12900379
Citation: https://journals.asm.org/doi/epdf/10.1128/aac.18.5.766

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