Compound ID | 3591

Update compound information

Miloxacin

Synonym(s): 5,8-dihydro-5-methoxy-8-oxo-2H-1,3-dioxolo-[4,5-g]quinoline-7-carboxylic acid  |  AB206

Class: Quinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against Escherichia coli, Klebsiella pneumoniae, Proteus sp., Serratia, Shigella sp., Salmonella sp., Enterobacter sp., Neisseria gonorrhoeae, and Haemophilus influenzae
Description: Synthetic compound; quinoline derivative; shows superior efficacy to nalidixic acid in mice infected with Escherichia coli and Klebsiella pneumoniae
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 263.2
Iso. SMILES: CON1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O
InChI Key: ABQYZRZVRIPTPI-UHFFFAOYSA-N
Can. SMILES: CON1C=C(C(=O)C2=C1C=C3C(=C2)OCO3)C(=O)O
InChI: InChI=1S/C12H9NO6/c1-17-13-4-7(12(15)16)11(14)6-2-9-10(3-8(6)13)19-5-18-9/h2-4H,5H2,1H3,(H,15,16)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/37614
Citations:
  • https://journals.asm.org/doi/10.1128/aac.17.5.763?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
  • https://journals.asm.org/doi/epdf/10.1128/aac.18.1.37

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