Compound ID | 3606

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Foramidocillin

Class: Beta-lactam

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli, Klebsiella sp., Enterobacter sp., Salmonella spp., Shigella spp., Pseudomonas aeruginosa, and Acinetobacter anitratus; cell wall synthesis inhibitor
Description: Semisynthetic compound derived from penicillin; resistant to hydrolysis by the following beta-lactamases: TEM-1, TEM-2, SHV-1, PSE-4, OXA-2, chromosomal beta-lactamases
Year first mentioned: 1986
Development status: Experimental
Chemical structure(s):
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Molecular weight: 592.58
Iso. SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC(=C(C=C2)O)O)C(=O)N[C@]3([C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O)NC=O
InChI Key: BLHZPPIRNRDRSC-HSDAMQNGSA-N
Can. SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C(=C2)O)O)C(=O)N[C@@]3(C(=O)N4[C@@H](C(=O)O)C(C)(C)S[C@H]34)NC=O
InChI: InChI=1S/C24H28N6O10S/c1-4-28-7-8-29(18(36)17(28)35)22(40)26-14(11-5-6-12(32)13(33)9-11)16(34)27-24(25-10-31)20(39)30-15(19(37)38)23(2,3)41-21(24)30/h5-6,9-10,14-15,21,32-33H,4,7-8H2,1-3H3,(H,25,31)(H,26,40)(H,27,34)(H,37,38)/t14-,15+,21-,24-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/72025
Citation: https://journals.asm.org/doi/10.1128/aac.29.5.769

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