Compound ID | 3608

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ICI 193428

Synonym(s): ICI-193428  |  ICI193428

Class: Beta-lactam

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Streptococcus sp., Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Enterobacter aerogenes (similar activity profile to ceftazidime); cell wall synthesis inhibitor
Description: Semisynthetic compound derived from cephalosporin
Year first mentioned: 1987
Development status: Experimental
Chemical structure(s):
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Molecular weight: 695.75
Iso. SMILES: O=C1[C@@H](NC(/C(/C2=CSC(N)=N2)=N/OC(C)(C(O)=O)(CC3=CC=C(C(N)=O)C=C3)C)=O)[C@@]4([H])SCC(CNC5=CC=[NH+]C=C5)=C(C([O-])=O)N14
InChI Key: LPGVZAKLWDMGAC-YEENEIFUSA-N
Can. SMILES: CC(C)(CC1=CC=C(C=C1)C(=O)N)(C(=O)O)O/N=C(\C2=CSC(=N2)N)/C(=O)N[C@@H]3C(=O)N4C(=C(CNC5=CC=[NH+]C=C5)CS[C@]34[H])C(=O)[O-]
InChI: InChI=1S/C30H31N8O8S2/c1-30(2,28(44)45,11-15-3-5-16(6-4-15)23(31)39)46-37-20(19-14-48-29(32)35-19)24(40)36-21-25(41)38-22(27(42)43)17(13-47-26(21)38)12-34-18-7-9-33-10-8-18/h3-10,14,21,26H,11-13H2,1-2H3,(H2,31,39)(H2,32,35)(H,33,34)(H,36,40)(H,42,43)(H,44,45)/b37-20+/t21-,26-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/135172810
Citation: https://journals.asm.org/doi/10.1128/aac.31.12.1997

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