Compound ID | 3617

Update compound information

N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-4-(1,3-oxazol-5-yl)benzamide

Synonym(s): Compound A

Class: Antivirulence agent (T3SS inhibitor)

Spectrum of activity: Gram-negative
Details of activity: Active against Yersinia sp.; likely targets the LcrF (VirF) transcription factor which regulates the Yersinia type III secretion system
Description: Synthetic compound; shows no intrinsic antibacterial activity nor cytotoxicity to mammalian cells
Year first mentioned: 2010
Development status: Experimental
Chemical structure(s):
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Molecular weight: 441.4
Iso. SMILES: C1=CC(=CC=C1C2=CN=CO2)C(=O)NC3=CC=C(C=C3)C4=NC5=C(N4O)C=C(C=C5)[N+](=O)[O-]
InChI Key: JVFIKDJRLZNUOA-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC=C1C2=CN=CO2)C(=O)NC3=CC=C(C=C3)C4=NC5=C(C=C(C=C5)[N+](=O)[O-])N4O
InChI: InChI=1S/C23H15N5O5/c29-23(16-3-1-14(2-4-16)21-12-24-13-33-21)25-17-7-5-15(6-8-17)22-26-19-10-9-18(28(31)32)11-20(19)27(22)30/h1-13,30H,(H,25,29)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11583023
Citation: https://journals.asm.org/doi/10.1128/iai.01305-09

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