ME1071

Class: Beta-lactamase inhibitor (MBL inhibitor)

Spectrum of activity:	Gram-negative
Details of activity:	Active against metallo-β-lactamase producing strains of Pseudomonas aeruginosa
Combined with other compounds:	Yes
Description:	Synthetic compound; maleic acid derivative; potentiates carbapenem and ceftazidime; no intrinsic antibacterial activity
Institute where first reported:	Meiji Seika Kaisha Ltd. (Tokyo, Japan)
Year first mentioned:	2010
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC/C(=C(\CC)/C(=O)[O-])/C(=O)[O-].[Na+].[Na+]
Isomeric SMILES:	CC/C(=C(\CC)/C(=O)[O-])/C(=O)[O-].[Na+].[Na+]
InChI:	InChI=1S/C8H12O4.2Na/c1-3-5(7(9)10)6(4-2)8(11)12;;/h3-4H2,1-2H3,(H,9,10)(H,11,12);;/q;2*+1/p-2/b6-5-;;
InChI Key:	GLJFFZOATODZQQ-XNOMRPDFSA-L

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/16064853
Main Source:	https://journals.asm.org/doi/10.1128/aac.01397-09