Compound ID | 362

Update compound information

DQ-2556

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad spectrum antibiotic which was comparable or superior to ceftazadime, cefotaxime and cefepime at inhibiting 90% of of Enterobacteriaceae tested. However, MRSA were resistant. Can be used against UTIs
Description: Chin NX, Huang HB and Neu HC. In vitro activity and β-lactamase stability of DQ-2556 compared to other agents. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 176
Institute where first reported: Daiichi Sankyo Pharmaceutical, Japan
Year first mentioned: 1988
Development status: Inactive
Reason Dropped: Some frequent side effects: diarrhoea, fever and skin eruptions, was in phase II for parenteral administration in Japan for UTI and then discontinued. This may be due to side effects (2)
Chemical structure(s):
Click here for structure editor
Molecular weight: 541.56
Iso. SMILES: CO/N=C(\C1=CSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=C(C=C4)C5=CN=CO5)C(=O)[O-]
InChI Key: IWIVCNVLSKNJJS-IFVXKBPSSA-N
Can. SMILES: CO/N=C(\C1=CSC(=N1)N)/C(=O)N[C@@H]2C(=O)N3C(=C(C[N+]4=CC=C(C=C4)C5=CN=CO5)CS[C@H]23)C(=O)[O-]
InChI: InChI=1S/C22H19N7O6S2/c1-34-27-15(13-9-37-22(23)25-13)18(30)26-16-19(31)29-17(21(32)33)12(8-36-20(16)29)7-28-4-2-11(3-5-28)14-6-24-10-35-14/h2-6,9-10,16,20H,7-8H2,1H3,(H3-,23,25,26,30,32,33)/b27-15+/t16-,20-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6917924
Citations:
  • https://www.jstage.jst.go.jp/article/chemotherapy1953/41/11/41_11_1195/_article
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC245513/
  • http://www.ncbi.nlm.nih.gov/pubmed/1482128

  • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.