Compound ID | 3621
DiPGLa-H
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus; membrane-active agent (targets both inner and outer cell membrane) |
| Description: | Semisynthetic compound; variant of the natural product PGLa from Xenopus laevis; has a therapeutic index of 35.94; reduced bacterial load by 1000-fold (Escherichia coli) or 100-fold (Staphylococcus aureus) in abdominal infection in mice |
| Year first mentioned: | 2025 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aem.02062-24 |
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.