Compound ID | 3625

Update compound information

ANASIA

Synonym(s): 2-amino-N-(amino-oxo-aryl-lambda6-sulfany lidene)acetamide  |  2-amino-n-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compound  |  ANASIA 124-1  |  ANASIA124-1

Class: Protein synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [Leu-RS] inhibitor)
Target Pathogen: Active against Escherichia coli, Enterobacter cloacae, and Haemophilus influenzae
Description: Synthetic compound; analogues with activity reported (i.e. ANASIA-124-1 with ; shows cytotoxicity towards human hepatic cell line HepG2 at > 64 mg/L (vs MIC at 0.7~4 mg/L) ; inferior to ciprofloxacin in treating Escherichia coli urinary tract infection in murine model
Institute where first reported: Oxford Drug Design Limited (UK)
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 309.84
Iso. SMILES: CC(C)C[C@@H](C(=O)N=S(=O)(C1=CC(=CS1)Cl)N)N
InChI Key: CPSZRVFKBBTTCF-RFXRWSEHSA-N
Can. SMILES: CC(C)C[C@@H](C(=O)N=S(=O)(C1=CC(=CS1)Cl)N)N
InChI: InChI=1S/C10H16ClN3O2S2/c1-6(2)3-8(12)10(15)14-18(13,16)9-4-7(11)5-17-9/h4-6,8H,3,12H2,1-2H3,(H2,13,14,15,16)/t8-,18?/m0/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/156530775
Guide to Pharmacology: ANASIA-124-1
Citation: https://patents.google.com/patent/WO2021123237A1
Patent: WO2021123237A1

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