Compound ID | 3628

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Aromatic acetylene derivative 13

Synonym(s): 5-hydroxy-4-[[(4R)-4-[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]-2-oxo-3-propan-2-ylimidazolidin-1-yl]methyl]-1H-pyrimidin-6-one

Class: Lipopolysaccharide synthesis inhibitor

Spectrum of activity: Gram-negative
Description: Synthetic compound; shows significant inhibitory effect in LpxC enzyme assay
Institute where first reported: Zhejiang Hisun Pharmaceutical Co., Ltd.; Shanghai Aryl Pharmtech Co., Ltd.
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 527.62
Iso. SMILES: CC(C)N1[C@@H](CN(C1=O)CC2=C(C(=O)NC=N2)O)C3=CC=C(C=C3)C#CC4=CC=C(C=C4)CN5CCOCC5
InChI Key: FPIRBASELPHEON-MHZLTWQESA-N
Can. SMILES: CC(C)N1[C@@H](CN(CC2=C(C(=O)NC=N2)O)C1=O)C3=CC=C(C#CC4=CC=C(C=C4)CN5CCOCC5)C=C3
InChI: InChI=1S/C30H33N5O4/c1-21(2)35-27(19-34(30(35)38)18-26-28(36)29(37)32-20-31-26)25-11-9-23(10-12-25)4-3-22-5-7-24(8-6-22)17-33-13-15-39-16-14-33/h5-12,20-21,27,36H,13-19H2,1-2H3,(H,31,32,37)/t27-/m0/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/167451510
Citation: https://patents.google.com/patent/WO2023011573A1/en
Patent: WO2023011573A1

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