Compound ID | 3631

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Triazolopyrimidine compound 24

Synonym(s): 2-Phenyl-N-(7-(pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl)acetamide

Class: Small molecule antibacterial agent

Description: Synthetic compound; has >51 selectivity index (MIC vs HepG2 CC50); shows improved microsomal stability in mice
Institute where first reported: Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States
Year first mentioned: 2025
Development status: Experimental
Chemical structure(s):
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Molecular weight: 330.34
Iso. SMILES: O=C(CC1=CC=CC=C1)NC2=CC(C3=CC=CC=N3)=NC4=NN=CN42
InChI Key: QKELQJLHTGKWGM-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)CC(=O)NC2=CC(=NC3=NN=CN23)C4=NC=CC=C4
InChI: InChI=1S/C18H14N6O/c25-17(10-13-6-2-1-3-7-13)22-16-11-15(14-8-4-5-9-19-14)21-18-23-20-12-24(16)18/h1-9,11-12H,10H2,(H,22,25)
External links:
Citation: https://pubs.acs.org/doi/10.1021/acsmedchemlett.5c00073

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