Compound ID | 3637

Update compound information

VUF15259

Synonym(s): VUF-15259  |  VUF 15259

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: BamA (Beta-barrel assembly machinery A) inhibitor and autotransporter pathway haemoglobin protease (Hbp) inhibitor (inhibits secretion of Hbp inducing cell envelope stress); T5SS inhibitor
Target Pathogen: Active against Escherichia coli
Description: Synthetic compound
Institute where first reported: Vrije Universiteit, Amsterdam
Year first mentioned: 2019
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: NC1CCN(CC(O)c2ccc(Cl)c(Cl)c2)CC1
InChI Key: YWXCHDWYZASSKE-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)Cl)Cl)C(CN2CCC(CC2)N)O
InChI: InChI=1S/C13H18Cl2N2O/c14-11-2-1-9(7-12(11)15)13(18)8-17-5-3-10(16)4-6-17/h1-2,7,10,13,18H,3-6,8,16H2
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/24277194
Citations:
  • https://www.nature.com/articles/s41579-023-00862-w
  • https://onlinelibrary.wiley.com/doi/10.1111/mmi.14255

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